Four-year HbA1c and LDL-cholesterol trajectories among individuals with mental disorders and newly developed type 2 diabetes

Brain Behav. 2021 Nov;11(11):e2372. doi: 10.1002/brb3.2372. Epub 2021 Sep 20.

Abstract

The impact of different types of mental disorders on long-term glycemic and lipid trajectories following newly diagnosed type 2 diabetes (T2D) remains unknown. We used real-world clinical data in a population-based cohort to fill this knowledge gap. We found that individuals with new T2D and preexisting personality, anxiety, unipolar depression, or psychotic disorder had higher mean HbA1c levels over 4 years following the onset of T2D, whereas no differences were found regarding LDL-C levels. This knowledge should be considered in the management of T2D in these vulnerable groups.

Keywords: LDL; cholesterol; diabetes mellitus; glycated hemoglobin a; glycemic control; mental disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose
  • Cholesterol, LDL
  • Diabetes Mellitus, Type 2*
  • Glycated Hemoglobin / analysis
  • Humans
  • Mental Disorders*

Substances

  • Blood Glucose
  • Cholesterol, LDL
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human