The Significance of Autoantibodies in Juvenile Dermatomyositis

Biomed Res Int. 2021 Nov 19:2021:5513544. doi: 10.1155/2021/5513544. eCollection 2021.

Abstract

Juvenile dermatomyositis is a chronic and rare autoimmune disorder classified into the spectrum of idiopathic inflammatory myopathies. Although this entity is mainly characterized by the presence of pathognomonic cutaneous lesions and proximal muscle weakness, the clinical manifestation can be highly heterogeneous; thus, diagnosis might be challenging. Current treatment recommendations for juvenile dermatomyositis, based mainly upon case series, include the use of corticosteroids, immunomodulatory, and immunosuppressive agents. Recently, several specific autoantibodies have been shown to be associated with distinct clinical phenotypes of classic dermatomyositis. There is a need to further evaluate their relevance in the formation of various clinical features. Furthermore, while providing more personalized treatment strategies, one should consider diversity of autoantibody-related subgroups of juvenile dermatomyositis.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / immunology
  • Amino Acyl-tRNA Synthetases / immunology
  • Antibody Specificity
  • Autoantibodies / blood*
  • Autoantigens / immunology
  • Child
  • DNA-Binding Proteins / immunology
  • Dermatomyositis / diagnosis
  • Dermatomyositis / immunology*
  • Dermatomyositis / therapy
  • Female
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / immunology
  • Interferon-Induced Helicase, IFIH1 / immunology
  • Male
  • Phenotype
  • Prognosis
  • Signal Recognition Particle / immunology
  • Small Ubiquitin-Related Modifier Proteins / immunology
  • Transcription Factors / immunology

Substances

  • Autoantibodies
  • Autoantigens
  • DNA-Binding Proteins
  • Mi-2 antibodies
  • Signal Recognition Particle
  • Small Ubiquitin-Related Modifier Proteins
  • TRIM33 protein, human
  • Transcription Factors
  • HMGCR protein, human
  • Hydroxymethylglutaryl CoA Reductases
  • Adenosine Triphosphatases
  • IFIH1 protein, human
  • MORC3 protein, human
  • Interferon-Induced Helicase, IFIH1
  • Amino Acyl-tRNA Synthetases