c-Maf: The magic wand that turns on LSEC fate

Anna R Smith; Valerie Gouon-Evans

doi:10.1016/j.stem.2022.03.011

c-Maf: The magic wand that turns on LSEC fate

Cell Stem Cell. 2022 Apr 7;29(4):491-493. doi: 10.1016/j.stem.2022.03.011.

Authors

Anna R Smith¹, Valerie Gouon-Evans²

Affiliations

¹ Section of Gastroenterology, Center for Regenerative Medicine (CReM), Department of Medicine, Boston University and Boston Medical Center, Boston, MA, USA.
² Section of Gastroenterology, Center for Regenerative Medicine (CReM), Department of Medicine, Boston University and Boston Medical Center, Boston, MA, USA. Electronic address: valerige@bu.edu.

PMID: 35395181
DOI: 10.1016/j.stem.2022.03.011

Abstract

In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs, and its overexpression specializes generic HUVECs into functional induced-LSECs, potentiating regenerative therapeutics.

Publication types

Comment

MeSH terms

Animals
Endothelial Cells* / cytology
Humans
Liver* / cytology
Mice
Proto-Oncogene Proteins c-maf*

Substances

MAF protein, human
Maf protein, mouse
Proto-Oncogene Proteins c-maf

Grants and funding

R01 DK124361/DK/NIDDK NIH HHS/United States