Chiari Malformation (Update on Diagnosis and Treatment)

Jared S Rosenblum; I Jonathan Pomeraniec; John D Heiss

doi:10.1016/j.ncl.2021.11.007

Chiari Malformation (Update on Diagnosis and Treatment)

Neurol Clin. 2022 May;40(2):297-307. doi: 10.1016/j.ncl.2021.11.007. Epub 2022 Mar 31.

Authors

Jared S Rosenblum¹, I Jonathan Pomeraniec², John D Heiss³

Affiliations

¹ National Institutes of Health, National Cancer Institute, Neuro-Oncology Branch, 37 Convent Drive, MSC 4254, Bethesda, MD, 20892 USA.
² National Institutes of Health, National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, 10 Center Drive, Room 3D20, Bethesda, MD, 20892 USA.
³ National Institutes of Health, National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch, 10 Center Drive, Room 3D20, Bethesda, MD, 20892 USA. Electronic address: heissj@ninds.nih.gov.

Abstract

Chiari Malformation Type I (CMI) is a congenital malformation diagnosed by MRI findings of at least 5 mm of cerebellar ectopy below the foramen magnum. CM1 is frequently associated with syringomyelia. Herein, we discuss the history of CMI and syringomyelia, including early pathological and surgical studies. We also describe recent investigations into the pathogenesis and pathophysiology of CMI and their practical implications on management and surgical intervention. We also highlight the recent development of the Common Data Elements for CMI, providing a framework for ongoing investigations. Finally, we discuss current controversies of surgical management in CMI.

Keywords: Chiari malformation; Diagnosis; Syrinx; Treatment.

Publication types

Review
Research Support, N.I.H., Intramural

MeSH terms

Arnold-Chiari Malformation* / diagnosis
Arnold-Chiari Malformation* / diagnostic imaging
Foramen Magnum / pathology
Foramen Magnum / surgery
Humans
Magnetic Resonance Imaging
Syringomyelia* / diagnostic imaging
Syringomyelia* / surgery

Abstract

Publication types

MeSH terms

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