The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan

Anticancer Res. 2022 Aug;42(8):3799-3806. doi: 10.21873/anticanres.15870.

Abstract

Background/aim: Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. Interleukin-8 (IL-8) is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature.

Materials and methods: IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology.

Results: The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (≤55) age.

Conclusion: IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.

Keywords: Breast cancer; Taiwan; genotype; interleukin-8; polymorphism.

MeSH terms

  • Case-Control Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Interleukin-8* / genetics
  • Polymorphism, Single Nucleotide
  • Taiwan / epidemiology
  • Triple Negative Breast Neoplasms* / genetics

Substances

  • CXCL8 protein, human
  • Interleukin-8