Location matters: hexokinase 1 in glucose metabolism and inflammation

Sivaraj M Sundaram; Luke A Doughty; Michael W Sereda

doi:10.1016/j.tem.2022.07.005

Location matters: hexokinase 1 in glucose metabolism and inflammation

Trends Endocrinol Metab. 2022 Oct;33(10):665-667. doi: 10.1016/j.tem.2022.07.005. Epub 2022 Aug 8.

Authors

Sivaraj M Sundaram¹, Luke A Doughty², Michael W Sereda³

Affiliations

¹ Department of Neurology, University Medical Center Goettingen, Goettingen, Germany; Research Group Translational Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany. Electronic address: mohana.sivaraj@mpinat.mpg.de.
² Department of Neurology, University Medical Center Goettingen, Goettingen, Germany; Research Group Translational Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany.
³ Department of Neurology, University Medical Center Goettingen, Goettingen, Germany; Research Group Translational Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany. Electronic address: sereda@mpinat.mpg.de.

PMID: 35953432
DOI: 10.1016/j.tem.2022.07.005

Abstract

Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.

Keywords: aging; deacetylation; diabetes; glucose metabolism; inflammation; nitrosylation.

Publication types

Comment

MeSH terms

Carbohydrate Metabolism
Glucose / metabolism
Hexokinase* / genetics
Hexokinase* / metabolism
Humans
Inflammation / metabolism
Mitochondria* / metabolism

Substances

HK1 protein, human
Hexokinase
Glucose