Comparative Evaluation of Efficacy of Bioactive Glass, Tricalcium Phosphate, and Ozone Remineralizing Agents on Artificial Carious Lesion

Debkant Jena; Abhigyan Manas; C H Venkateswararao; Mohamed Tharwat Salama; Prabu Mahin Syed Ismail; Shaik Riyaz Basha

doi:10.4103/jpbs.jpbs_117_22

Comparative Evaluation of Efficacy of Bioactive Glass, Tricalcium Phosphate, and Ozone Remineralizing Agents on Artificial Carious Lesion

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S959-S961. doi: 10.4103/jpbs.jpbs_117_22. Epub 2022 Jul 13.

Authors

Debkant Jena¹, Abhigyan Manas², C H Venkateswararao³, Mohamed Tharwat Salama⁴, Prabu Mahin Syed Ismail⁵, Shaik Riyaz Basha⁶

Affiliations

¹ Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, SOA Deemed to be University, K8 Kalinga Nagar, Bhubaneswar, Odhisa, India.
² Senior Resident, Department of Dentistry, UP University of Medical Sciences, Saifai, Utter Pradesh, India.
³ Department of Oral and Maxillofacial Surgery, Department of Dentistry, Nimra Institute of Medical Sciences, Jupudi, Vijayawada, Andra Pradesh, India.
⁴ Department of Preventive Dentistry, College of Dentistry in Ar Rass Qassim University, Kingdom of Saudi Arabia, Kingdom of Saudia.
⁵ Department of Restorative Dentistry, College of Dentistry in Al Rass Qassim University, Kingdom of Saudi Arabia.
⁶ Reader, Department of Prosthodontics, Mallareddy Institute of Dental Sciences, India.

Abstract

Objectives: Evaluation of efficacy of bioactive glass (BAG), tricalcium phosphate, and ozone remineralizing agents on artificial carious lesion.

Materials and methods: Freshly extracted 48 human premolar teeth were included for this in vitro study. Remineralization of demineralized teeth was done with respective remineralizing agents (Group A - calcium sodium phosphosilicate [BAG], Group B - tricalcium phosphate [Clinpro Tooth Crème], Group C - ozone remineralizing agents, and control group: Group D - deionized water) three times a day for 12 days for 4 min. The degree of demineralization and remineralization was evaluated with Vickers hardness number.

Results: There was a decrease in microhardness from baseline to demineralization in all the groups. The difference in microhardness values from demineralization to remineralization in all the three test groups was found to be statistically highly significant.

Conclusion: BAG and Tricalcium phosphate had higher remineralizing capacity, which can be used clinically to treat early carious lesions.

Keywords: Bioactive glass; dental caries; ozone; remineralization; tricalcium phosphate.