KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury

Kidney360. 2022 May 6;3(8):1417-1422. doi: 10.34067/KID.0002272022. eCollection 2022 Aug 25.

Abstract

Discovering new nephroprotectants may provide therapeutic strategies in AKI.This study provides the first evidence that KLF11, a member of the Krüppel-like factor (KLF) family of proteins, protects against AKI.In the absence of KLF11, exaggerated induction of endothelin-1 and IL-6 occurs after ischemic renal injury and may contribute to worse AKI.

Keywords: IL-6; KLF11; acute kidney injury; acute kidney injury and ICU nephrology; basic science; endothelin-1; heme oxygenase-1; protectant; reperfusion injury.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Kidney Injury* / prevention & control
  • Apoptosis Regulatory Proteins* / metabolism
  • Endothelin-1 / metabolism
  • Humans
  • Interleukin-6 / metabolism
  • Kidney / metabolism
  • Kruppel-Like Transcription Factors / genetics
  • Protective Agents / metabolism
  • Reperfusion Injury* / prevention & control
  • Repressor Proteins* / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • Endothelin-1
  • Interleukin-6
  • KLF11 protein, human
  • Kruppel-Like Transcription Factors
  • Protective Agents
  • Repressor Proteins