SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

Guanqin Ma; Deng-Feng Zhang; Qing-Cui Zou; Xiaochun Xie; Ling Xu; Xiao-Li Feng; Xiaohong Li; Jian-Bao Han; Dandan Yu; Zhong-Hua Deng; Wang Qu; Junyi Long; Ming-Hua Li; Yong-Gang Yao; Jianxiong Zeng

doi:10.1038/s41421-022-00458-3

SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

Cell Discov. 2022 Sep 30;8(1):99. doi: 10.1038/s41421-022-00458-3.

Authors

Guanqin Ma^#¹, Deng-Feng Zhang^#^{1

2

3}, Qing-Cui Zou^#², Xiaochun Xie^#¹, Ling Xu^{1

2

3}, Xiao-Li Feng², Xiaohong Li¹, Jian-Bao Han², Dandan Yu^{1

2

3}, Zhong-Hua Deng², Wang Qu², Junyi Long², Ming-Hua Li⁴, Yong-Gang Yao^{5

6

7

8}, Jianxiong Zeng^{9

10

11

12}

Affiliations

¹ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
² Kunming National High-level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
³ Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
⁴ Kunming National High-level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. limh@mail.kiz.ac.cn.
⁵ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.
⁶ Kunming National High-level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.
⁷ Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China. yaoyg@mail.kiz.ac.cn.
⁸ CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. yaoyg@mail.kiz.ac.cn.
⁹ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. zengjianxiong@mail.kiz.ac.cn.
¹⁰ Kunming National High-level Biosafety Research Center for Non-Human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. zengjianxiong@mail.kiz.ac.cn.
¹¹ Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China. zengjianxiong@mail.kiz.ac.cn.
¹² Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. zengjianxiong@mail.kiz.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter