Engineering biology for sustainable 1,4-butanediol synthesis

Connor L Trotter; Gautham S Babu; Stephen Wallace

doi:10.1016/j.tibtech.2023.01.006

Engineering biology for sustainable 1,4-butanediol synthesis

Trends Biotechnol. 2023 Mar;41(3):286-288. doi: 10.1016/j.tibtech.2023.01.006. Epub 2023 Jan 24.

Authors

Connor L Trotter¹, Gautham S Babu¹, Stephen Wallace²

Affiliations

¹ Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Roger Land Building, Alexander Crum Brown Road, King's Buildings, Edinburgh, EH9 3FF, UK.
² Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Roger Land Building, Alexander Crum Brown Road, King's Buildings, Edinburgh, EH9 3FF, UK. Electronic address: stephen.wallace@ed.ac.uk.

PMID: 36697283
DOI: 10.1016/j.tibtech.2023.01.006

Abstract

Over the past decade, numerous approaches have been taken to replace unsustainable chemical syntheses with green biosynthetic alternatives. In a landmark paper, Yim et al. utilised an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol in the bacterium Escherichia coli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biology
Butylene Glycols* / chemistry
Escherichia coli* / genetics
Fermentation
Metabolic Engineering

Substances

1,4-butanediol
Butylene Glycols

Grants and funding

MR/S033882/1/MRC_/Medical Research Council/United Kingdom