HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first time in Amerindians (Cuenca city area, Ecuador). It was found that most common extended haplotypes gathered the most frequent HLA-DRB1 Amerindian alleles. HLA-DMB polymorphism studies may be important to uncover HLA and diseases pathogenesis and also in an extended HLA haplotype frameshift. HLA-DM molecule has a crucial role together with CLIP protein in HLA class II peptide presentation. HLA extended haplotypes including complement and non classical genes alleles are proposed to HLA and disease studies.
Keywords: Amerindians; Arthritis; Autoimmunity; CLIP; Diabetes; Diseases; Ecuador; HLA-DM; HLA-DMB; HLA-DO; HLA-DQB1; HLA-DRB1; Psoriasis; SLE.
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