Objective: To evaluate the associations between the renalase single-nucleotide polymorphisms rs2576178 and rs10887800 and the risk of hypertension in OSA patients. Methods: A total of 3, 570 male OSA subjects diagnosed via standard polysomnography were included in this retrospective study. We recorded anthropometric, genomic, and polysomnographic parameters and blood pressure levels. All subjects were divided into four groups based on quartiles of the apnea-hypopnea index (AHI). The relationships between rs2576178 and rs10887800 and the risk of hypertension were evaluated using the binary logistic regression, and haplotype analysis. Results: In the bottom AHI quartile, rs10887800 was significantly associated with the risk of hypertension according to the dominant model [odds ratio(OR)=0.691, 95% confidence interval (CI)=0.483-0.990, P=0.044] even after adjustment for age, sex, and the body mass index. The G-A haplotype was associated with a co-effect of the two SNPs, namely, the risk of hypertension decreased (OR=0.879, 95%CI=0.784-0.986, P=0.028). Conclusions: We find no association between single rs2576178 or rs10887800 variants with the risk of hypertension in our OSA population. But, the synergistic effect of the two polymorphisms is associated with the risk of hypertension in OSA patients.
目的： 探讨肾胺酶基因rs2576178和rs10887800多态性与阻塞性睡眠呼吸暂停（OSA）患者高血压风险之间的关系。 方法： 该回顾性研究连续纳入2008年7月—2018年10月于上海市第六人民医院睡眠中心基因库中经标准多导睡眠监测（PSG）诊断的3 570例疑似OSA的男性患者，年龄18~97（42.2±11.9）岁，并收集其人体测量学指标、多导睡眠呼吸参数和血压水平。所有受试者根据呼吸暂停低通气指数（AHI）的四分位间距分组。从基因库中提取rs2576178和rs10887800位点的基因型数据，采用二元logistic回归及单倍型分析等统计方法探讨rs2576178和rs10887800变异与OSA患者高血压风险的相关性。 结果： 二元logistic回归分析发现，在校正年龄和体质量指数（BMI）后，AHI四分位间距的最低组中，rs10887800的显性模型与高血压的风险相关（OR=0.691，95%CI为0.483~0.990，P=0.044）。此外，rs2576178与rs10887800的G-A单倍型对降低高血压的风险有协同效应（OR=0.879，95%CI为0.784~0.986，P=0.028）。 结论： 单个rs2576178和rs10887800变异与OSA人群高血压无明显相关性，但2个多态性位点的协同效应与OSA患者高血压的发病风险相关。.