Abstract
The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cattle
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Cytochrome Reductases / genetics*
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DNA, Mitochondrial / genetics*
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Genes
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Humans
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Intracellular Membranes
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Macromolecular Substances
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Molecular Weight
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NAD(P)H Dehydrogenase (Quinone)
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NADH Dehydrogenase / genetics*
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NADH Dehydrogenase / immunology
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NADH, NADPH Oxidoreductases / genetics*
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Quinone Reductases / genetics*
Substances
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DNA, Mitochondrial
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Macromolecular Substances
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NADH, NADPH Oxidoreductases
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Cytochrome Reductases
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NAD(P)H Dehydrogenase (Quinone)
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Quinone Reductases
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NADH Dehydrogenase