Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

Pharmacology. 1974;11(3):151-69. doi: 10.1159/000136485.
No abstract available

MeSH terms

  • Animals
  • Benzene Derivatives / metabolism
  • Benzene Derivatives / pharmacology*
  • Biotransformation
  • Carbon Radioisotopes
  • Chemical and Drug Induced Liver Injury*
  • Cysteine / pharmacology
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Glutathione / metabolism*
  • Hydrocarbons, Brominated / metabolism
  • Hydrocarbons, Brominated / pharmacology
  • In Vitro Techniques
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Maleates / pharmacology
  • Microsomes, Liver / metabolism*
  • Necrosis / chemically induced*
  • Oxidation-Reduction
  • Phenobarbital / pharmacology
  • Proadifen / pharmacology
  • Protein Binding
  • Rats

Substances

  • Benzene Derivatives
  • Carbon Radioisotopes
  • Hydrocarbons, Brominated
  • Maleates
  • Proadifen
  • Glutathione
  • Cysteine
  • Phenobarbital