Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus

EMBO J. 1982;1(7):869-74. doi: 10.1002/j.1460-2075.1982.tb01262.x.

Abstract

A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha-helix.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Viral*
  • Antigen-Antibody Complex
  • Antigens, Viral* / genetics
  • Aphthovirus / genetics
  • Aphthovirus / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / analysis*
  • Genes, Viral
  • Serotyping

Substances

  • Antibodies, Viral
  • Antigen-Antibody Complex
  • Antigens, Viral
  • Epitopes