A nonpolymorphic class I gene in the murine major histocompatibility complex

Cell. 1984 Jan;36(1):139-44. doi: 10.1016/0092-8674(84)90082-5.

Abstract

DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.

MeSH terms

  • Alleles
  • Animals
  • Antigens, Surface / genetics*
  • Base Sequence
  • DNA / genetics
  • Genes, MHC Class II*
  • H-2 Antigens / genetics*
  • Histocompatibility Antigens Class I*
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Polymorphism, Genetic

Substances

  • Antigens, Surface
  • H-2 Antigens
  • Histocompatibility Antigens Class I
  • Q surface antigens
  • DNA

Associated data

  • GENBANK/K01205
  • GENBANK/K01206
  • GENBANK/K01207