Xipamide: no advantage over bendrofluazide in hypertension

Br J Clin Pharmacol. 1984 Oct;18(4):616-8. doi: 10.1111/j.1365-2125.1984.tb02514.x.

Abstract

In patients with uncontrolled hypertension addition of xipamide 20 mg daily to bendrofluazide 5 mg daily produced no significant additive antihypertensive effect, and the 95% confidence limits excluded a clinically important response. Xipamide treatment worsened hypokalaemia and increased the blood urea concentration significantly.

Publication types

  • Comparative Study

MeSH terms

  • Bendroflumethiazide / administration & dosage*
  • Blood Pressure / drug effects
  • Diuretics / administration & dosage*
  • Drug Synergism
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Middle Aged
  • Random Allocation
  • Xipamide / administration & dosage*

Substances

  • Diuretics
  • Xipamide
  • Bendroflumethiazide