Abstract
In patients with uncontrolled hypertension addition of xipamide 20 mg daily to bendrofluazide 5 mg daily produced no significant additive antihypertensive effect, and the 95% confidence limits excluded a clinically important response. Xipamide treatment worsened hypokalaemia and increased the blood urea concentration significantly.
MeSH terms
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Bendroflumethiazide / administration & dosage*
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Blood Pressure / drug effects
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Diuretics / administration & dosage*
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Drug Synergism
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Drug Therapy, Combination
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Female
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Humans
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Hypertension / drug therapy*
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Male
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Middle Aged
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Random Allocation
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Xipamide / administration & dosage*
Substances
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Diuretics
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Xipamide
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Bendroflumethiazide