Differentiation of chronic lymphocytic leukemia from Hodgkin's disease using immunologic marker studies

Am J Surg Pathol. 1981 Oct;5(7):707-10. doi: 10.1097/00000478-198110000-00014.

Abstract

Four consecutive lymph node biopsies from one patient showed features typical of lymphocyte-pre-dominant Hodgkin's disease. When the patient developed lymphocytosis of the peripheral blood and a staging bone marrow biopsy was found to have nodular lymphoid infiltrates atypical for Hodgkin's disease, the fourth node biopsy was performed in order to perform immunologic marker studies. A monoclonal cell population was identified and the lymph nodes were interpreted as chronic lymphocytic leukemia mimicking lymphocyte-predominant Hodgkin's disease. The diagnostic usefulness of immunologic marker studies stressed.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Diagnosis, Differential
  • Fluorescent Antibody Technique
  • Hodgkin Disease / immunology*
  • Humans
  • Leukemia, Lymphoid / immunology*
  • Leukemia, Lymphoid / pathology
  • Lymph Nodes / immunology
  • Lymph Nodes / pathology
  • Male
  • Middle Aged