Selective depletion of spinal noradrenaline inhibits post-decapitation convulsions in rats

Experientia. 1980 Feb 15;36(2):224. doi: 10.1007/BF01953745.

Abstract

Local administration of 6-hydroxydopamine in the subarachnoidal space of the spinal cord in rats resulted in a selective long-lasting depletion of spinal noradrenaline, but not of dopamine, and prevented the occurrence of post-decapitation convulsions.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / physiology*
  • Brain / physiopathology
  • Dopamine / physiology*
  • Hydroxydopamines / pharmacology*
  • Male
  • Norepinephrine / physiology*
  • Postmortem Changes
  • Rats
  • Seizures / physiopathology*
  • Spinal Cord / drug effects
  • Spinal Cord / physiology*
  • Spinal Cord / physiopathology

Substances

  • Hydroxydopamines
  • Dopamine
  • Norepinephrine