Identification of a new locus, mus115, in Drosophila melanogaster

Mutat Res. 1993 Feb;301(2):121-4. doi: 10.1016/0165-7992(93)90034-s.

Abstract

Previous screens for autosomal genes that are necessary for resistance to DNA cross-linking agents but not to monofunctional agents have produced 6 mutations; all of which fall within the third chromosomal gene mus308. In an effort to identify analogous sex-linked genes, a screen of mutagenized X-chromosomes has been conducted for mutations that confer hypersensitivity to nitrogen mustard. This search has identified a new locus, mus115, through the recovery of a mutant that is strongly hypersensitive to nitrogen mustard but marginally sensitive to methyl methanesulfonate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drosophila melanogaster / genetics*
  • Female
  • Genes, Insect / drug effects*
  • Genetic Complementation Test
  • Genetic Linkage
  • Male
  • Methyl Methanesulfonate / toxicity
  • Mutagenesis*
  • Mutagenicity Tests*
  • Nitrogen Mustard Compounds / toxicity
  • X Chromosome

Substances

  • Nitrogen Mustard Compounds
  • Methyl Methanesulfonate