T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects

J Infect Dis. 1995 Mar;171(3):531-6. doi: 10.1093/infdis/171.3.531.

Abstract

The predictive value of low T cell reactivity to CD3 monoclonal antibodies for development of AIDS was evaluated and compared with low CD4+ cell numbers and the presence of syncytium-inducing human immunodeficiency virus (HIV) variants in 122 seropositive asymptomatic homosexual men for 4.5 years. Low T cell reactivity was a strong predictor for progression to AIDS in a multivariate proportional hazards analysis using these markers as covariates at entry and as time-dependent covariates. The combination of the three markers was associated with development of AIDS in 6 of 7 men within 15 months. In contrast, the group that lacked any of these markers had a very low risk (11%) for developing AIDS. In groups with one or two of these three markers, progression rates were 33% and 66%, respectively. These data demonstrate that measurement of T cell function in vitro is of value for staging of HIV infection and may be useful for monitoring therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Adult
  • Biomarkers
  • CD4 Lymphocyte Count
  • Humans
  • Male
  • Multivariate Analysis
  • T-Lymphocytes / immunology*

Substances

  • Biomarkers