Abstract
The effect of Sho-saiko-to on the concentration of vitamin E in serum and on the granuloma formation in Carrageenin cotton pellet-induced rats was investigated. As a result, in the granuloma rats of Sho-saiko-to group, a significantly improved inhibitory effect on granuloma formation and a higher concentration of vitamin E in serum, cholesterol and phospholipid were observed compared to the control group. Despite this lipid-increasing action by Sho-saiko-to, the concentration of serum lipid peroxide was significantly lower than in the control group. Furthermore, a significant negative correlation between the concentration of vitamin E and granuloma weight was observed. These results suggest that vitamin E plays an important role in promoting the anti-inflammatory effect of Sho-saiko-to.
MeSH terms
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Administration, Oral
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Carrageenan / toxicity
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Cholesterol / blood
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Disease Models, Animal
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Drug Synergism
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Drugs, Chinese Herbal / administration & dosage
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Drugs, Chinese Herbal / pharmacology*
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Drugs, Chinese Herbal / therapeutic use
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Granuloma / chemically induced
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Granuloma / drug therapy*
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Lipid Peroxidation / drug effects
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Male
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Phospholipids / blood
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Rats
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Rats, Wistar
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Vitamin E / blood*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Drugs, Chinese Herbal
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Phospholipids
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Vitamin E
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saiko-keishi-to
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Carrageenan
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Cholesterol