Minireview: trichosanthin--a protein with multiple pharmacological properties

Life Sci. 1994;55(4):253-62. doi: 10.1016/0024-3205(94)00727-6.

Abstract

Trichosanthin (TCS), a protein isolated from the root tuber of the Chinese medicinal herb Trichosanthes kirilowii Maxim., is used to induce abortion in China. It also possesses immunomodulatory, anti-tumor and anti-human immunodeficiency virus properties. TCS is a member of the family of ribosome-inactivating proteins and inactivates eukaryotic ribosomes via its N-glycosidase activity. The gene encoding TCS has been cloned and over-expressed and the crystal structure of this protein resolved to 1.73A. In this review, the various pharmacological properties of TCS are discussed and assessed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abortifacient Agents / pharmacology*
  • Adjuvants, Immunologic / pharmacology
  • Antineoplastic Agents / pharmacology*
  • Antiviral Agents / pharmacology*
  • Female
  • HIV / drug effects
  • Humans
  • Immunologic Factors / pharmacology*
  • Pregnancy
  • Trichosanthin / pharmacology*

Substances

  • Abortifacient Agents
  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Antiviral Agents
  • Immunologic Factors
  • Trichosanthin