Abstract
To elucidate sites of SRV-2/W persistence, tissue DNA from three groups of naturally infected Macaca nemestrina was analyzed for provirus: vertically transmitted, viremic, seronegative macaques; horizontally transmitted, viremic, seronegative macaques, and nonviremic seropositive macaques. In viremic animals infected vertically, provirus was found in many tissues, whereas in those infected horizontally, proviral DNA was limited. In V-Ab+ macaques, provirus was detected in bone marrow and/or ileocecal junction, confirming the presence of provirus in V-Ab+ animals.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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DNA, Viral / analysis
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Female
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Macaca nemestrina / microbiology*
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Male
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Monkey Diseases / epidemiology
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Monkey Diseases / microbiology*
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Prevalence
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Proviruses / isolation & purification
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Retroviridae Infections / epidemiology
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Retroviridae Infections / microbiology
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Retroviridae Infections / veterinary*
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Retroviruses, Simian / genetics
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Retroviruses, Simian / immunology
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Retroviruses, Simian / isolation & purification*
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Seroepidemiologic Studies
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Simian Acquired Immunodeficiency Syndrome / epidemiology
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Tumor Virus Infections / epidemiology
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Tumor Virus Infections / microbiology
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Tumor Virus Infections / veterinary*
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Viremia / microbiology
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Viremia / veterinary