Blood and urinary concentrations of fosfomycin as a function of the renal function value

Chemotherapy. 1977:23 Suppl 1:196-9. doi: 10.1159/000222047.

Abstract

The following parameters were considered in studying 43 subjects under treatment for urinary infections with different degrees of renal insufficiency: the maximum blood concentrations, the plasmatic half-life, and the urinary concentrations of fosfomycin as a function of the plasma creatinine of the subject treated. The curve of the average maximum blood concentrations show a parabola-like increase, the plasmatic half-life followed the same tendency, while the curve of the average urinary concentrations presented an exponential decrease. The urinary concentrations were, nevertheless, always higher than 100 mug/ml regardless of the degree of renal insufficiency and even in the subjects who had a very high plasma creatinine. Given its absence of renal and systemic toxicity, the daily dosage of fosfomycin could remain unchanged regardless of the degree of insufficiency.

MeSH terms

  • Anti-Bacterial Agents / blood*
  • Anti-Bacterial Agents / urine*
  • Fosfomycin / blood*
  • Fosfomycin / therapeutic use
  • Fosfomycin / urine*
  • Half-Life
  • Humans
  • Kidney Function Tests
  • Urinary Tract Infections / blood
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / urine

Substances

  • Anti-Bacterial Agents
  • Fosfomycin