Mutations in tumour suppressor gene p53 in two feline fibrosarcomas

B Mayr; G Schaffner; R Kurzbauer; A Schneider; M Reifinger; G Loupal

doi:10.1016/s0007-1935(95)80151-0

Mutations in tumour suppressor gene p53 in two feline fibrosarcomas

Br Vet J. 1995 Nov-Dec;151(6):707-13. doi: 10.1016/s0007-1935(95)80151-0.

Authors

B Mayr¹, G Schaffner, R Kurzbauer, A Schneider, M Reifinger, G Loupal

Affiliation

¹ Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.

PMID: 8605583
DOI: 10.1016/s0007-1935(95)80151-0

Abstract

Exons 5-7 of the tumour suppressor gene p53 were investigated in genomic DNA of tumours of domestic cats. In one fibrosarcoma investigated we observed a mutation GAG-->AAG (glutamic acid-->lysine) in codon 180; in another there was a mutation CGG-->TGG (arginine-->tryptophane) in codon 248.

MeSH terms

Animals
Base Sequence
Cat Diseases / genetics*
Cats
Fibrosarcoma / genetics
Fibrosarcoma / veterinary*
Genes, p53 / genetics*
Male
Molecular Sequence Data
Point Mutation / genetics*