TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

Science. 1996 May 24;272(5265):1179-82. doi: 10.1126/science.272.5265.1179.

Abstract

Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Line
  • Cloning, Molecular
  • Enzyme Activation
  • Genes, Reporter
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • MAP Kinase Kinase Kinases*
  • Mice
  • Molecular Sequence Data
  • Plasminogen Activator Inhibitor 1 / genetics
  • Promoter Regions, Genetic
  • Protein Serine-Threonine Kinases / metabolism*
  • Recombinant Fusion Proteins / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Signal Transduction*
  • Transfection
  • Transformation, Genetic
  • Transforming Growth Factor beta / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Plasminogen Activator Inhibitor 1
  • Recombinant Fusion Proteins
  • TAB1 protein, MAPKKK activator, vertebrate
  • TAB1 protein, human
  • Transforming Growth Factor beta
  • Protein Serine-Threonine Kinases
  • MAP Kinase Kinase Kinases
  • MAP kinase kinase kinase 7

Associated data

  • GENBANK/U49928