Olfactory receptor-encoding genes and pseudogenes are expressed in humans

M L Crowe; B N Perry; I F Connerton

doi:10.1016/0378-1119(95)00849-7

Olfactory receptor-encoding genes and pseudogenes are expressed in humans

Gene. 1996 Mar 9;169(2):247-9. doi: 10.1016/0378-1119(95)00849-7.

Authors

M L Crowe¹, B N Perry, I F Connerton

Affiliation

¹ Protein Engineering Department, Institute of Food Research, Reading, UK.

PMID: 8647456
DOI: 10.1016/0378-1119(95)00849-7

Abstract

A putative olfactory receptor-encoding gene was cloned from human genomic DNA and shown to be expressed by isolation of a full-length cDNA from olfactory tissue. A second cDNA clone was found to encode an olfactory receptor pseudogene. The expression of a pseudogene from the olfactory gene repertoire, in neurons which express only a single receptor type, implies that many neurons will be non-functional.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
DNA, Complementary
Humans
Molecular Sequence Data
Pseudogenes / genetics
Receptors, Cell Surface / chemistry
Receptors, Cell Surface / genetics*
Receptors, G-Protein-Coupled*
Receptors, Odorant / genetics*

Substances

DNA, Complementary
OR3A1 protein, human
Receptors, Cell Surface
Receptors, G-Protein-Coupled
Receptors, Odorant

Associated data

GENBANK/X80391
GENBANK/X87825