Abstract
The gene cul-1 (formerly lin-19) is a negative regulator of the cell cycle in C. elegans. Null mutations cause hyperplasia of all tissues. cul-1 is required for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway. Moreover, the mutant phenotype suggests that G1-to-S phase progression is accelerated, overriding mechanisms for mitotic arrest and producing abnormally small cells. Significantly, diverse aspects of cell fate and differentiation are unaffected in cul-1 mutants. cul-1 represents a conserved family of genes, designated cullins, with at least five members in nematodes, six in humans, and three in budding yeast.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Apoptosis / physiology
-
Base Sequence
-
Caenorhabditis elegans / chemistry
-
Caenorhabditis elegans / embryology
-
Caenorhabditis elegans / genetics*
-
Cell Cycle / physiology*
-
Cell Cycle Proteins*
-
Chromosome Mapping
-
Cloning, Molecular
-
Cullin Proteins*
-
DNA, Complementary / genetics
-
Genes, Helminth / genetics*
-
Germ Layers
-
Helminth Proteins / chemistry
-
Helminth Proteins / genetics*
-
Helminth Proteins / physiology
-
Humans
-
Larva
-
Molecular Sequence Data
-
Mutation
-
RNA, Helminth / genetics
-
RNA, Messenger / genetics
-
Sequence Analysis, DNA
-
Sequence Homology, Amino Acid
-
Yeasts
Substances
-
Cell Cycle Proteins
-
Cullin 1
-
Cullin Proteins
-
DNA, Complementary
-
Helminth Proteins
-
RNA, Helminth
-
RNA, Messenger
Associated data
-
GENBANK/U58083
-
GENBANK/U58084
-
GENBANK/U58085
-
GENBANK/U58086
-
GENBANK/U58087
-
GENBANK/U58088
-
GENBANK/U58089
-
GENBANK/U58090
-
GENBANK/U58091