Abstract
A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide amide Phe-Met-Arg-Phe-NH2. Its structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis. This neuropeptide is active at about 10(-8)M when assayed on molluscan muscle.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Bivalvia / analysis*
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Ganglia / analysis
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Heart / drug effects*
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Muscle Contraction / drug effects
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Nerve Tissue Proteins* / isolation & purification
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Nerve Tissue Proteins* / pharmacology
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Oligopeptides* / isolation & purification
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Oligopeptides* / pharmacology
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Structure-Activity Relationship
Substances
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Nerve Tissue Proteins
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Oligopeptides