Sequence of the cDNA for the liver/non-muscle isoform of mouse cytochrome-c oxidase subunit VIII

Biochim Biophys Acta. 1996 Sep 11;1308(3):197-200. doi: 10.1016/0167-4781(96)00122-4.

Abstract

We have isolated and sequenced the cDNA for the liver (L) or non-muscle isoform of mouse cytochrome-c oxidase subunit VIII (COX VIII-L). Comparison of deduced COX VIII-L protein sequences from three mammalian species indicated that the human gene has sustained more amino acid replacement substitutions than either the mouse or the cow. The most highly conserved regions of this subunit are the N-terminal presequence and the C-terminal domain of the mature protein.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • Cloning, Molecular
  • Conserved Sequence / genetics
  • DNA, Complementary / genetics*
  • Electron Transport Complex IV / chemistry
  • Electron Transport Complex IV / genetics*
  • Evolution, Molecular
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / genetics*
  • Liver / enzymology*
  • Mice
  • Molecular Sequence Data
  • Sequence Analysis
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • Isoenzymes
  • Electron Transport Complex IV

Associated data

  • GENBANK/U37721