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Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cells.
Biochem J. 1997 Jan 15;321 ( Pt 2)(Pt 2):367-73. doi: 10.1042/bj3210367.
Biochem J. 1997.
PMID: 9020868
Free PMC article.
Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.
Winters A, Ramos-Molina B, Jarvela TS, Yerges-Armstrong L, Pollin TI, Lindberg I.
Winters A, et al.
Diabetes Res Clin Pract. 2017 Sep;131:82-90. doi: 10.1016/j.diabres.2017.06.023. Epub 2017 Jul 3.
Diabetes Res Clin Pract. 2017.
PMID: 28719828
Free PMC article.
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