TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)

J L Bodmer; K Burns; P Schneider; K Hofmann; V Steiner; M Thome; T Bornand; M Hahne; M Schröter; K Becker; A Wilson; L E French; J L Browning; H R MacDonald; J Tschopp

doi:10.1016/s1074-7613(00)80244-7

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)

Immunity. 1997 Jan;6(1):79-88. doi: 10.1016/s1074-7613(00)80244-7.

Authors

J L Bodmer¹, K Burns, P Schneider, K Hofmann, V Steiner, M Thome, T Bornand, M Hahne, M Schröter, K Becker, A Wilson, L E French, J L Browning, H R MacDonald, J Tschopp

Affiliation

¹ Institute of Biochemistry, University of Lausanne, Switzerland.

PMID: 9052839
DOI: 10.1016/s1074-7613(00)80244-7

Abstract

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing*
Amino Acid Sequence
Apoptosis Regulatory Proteins
Apoptosis*
Carrier Proteins / metabolism
Chromosomes, Human, Pair 1
Cytoplasm / chemistry
Fas Ligand Protein
Fas-Associated Death Domain Protein
Gene Expression
Humans
Ligands
Lymphocytes / physiology*
Membrane Glycoproteins / metabolism
Molecular Sequence Data
Multigene Family
NF-kappa B / physiology
RNA, Messenger / genetics
Receptors, Cell Surface / physiology*
Receptors, Tumor Necrosis Factor / genetics
Receptors, Tumor Necrosis Factor / physiology*
Receptors, Tumor Necrosis Factor, Member 25
Sequence Alignment
Sequence Homology, Amino Acid
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha / metabolism

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
Carrier Proteins
FADD protein, human
FASLG protein, human
Fas Ligand Protein
Fas-Associated Death Domain Protein
Ligands
Membrane Glycoproteins
NF-kappa B
RNA, Messenger
Receptors, Cell Surface
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Member 25
TNF-Related Apoptosis-Inducing Ligand
TNFRSF25 protein, human
TNFSF10 protein, human
Tumor Necrosis Factor-alpha

Associated data

GENBANK/U75380
GENBANK/U75381