Abstract
A patient with chronic bromvalerylurea poisoning showed cerebellar ataxia and peripheral neuropathy. The patient was a 42-year-old Japanese man who developed consciousness disturbance, diplopia, slurred speech, ataxia and gait disturbance after having taken bromvalerylurea for ten years. Magnetic resonance imaging revealed atrophy of the cerebellum and pontine tegmentum. An electrophysiological study revealed decreased motor nerve conduction velocity and amplitude of compound muscle action potentials of the right tibial nerve. Histological findings of the left sural nerve indicated a slightly decreased large myelinated fiber diameter, which suggested chronic axonal damage.
MeSH terms
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Adult
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Atrophy
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Biopsy
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Bromisovalum / poisoning*
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Cerebellar Ataxia / chemically induced*
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Cerebellar Ataxia / diagnosis
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Cerebellar Ataxia / physiopathology
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Cerebellum / drug effects
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Cerebellum / pathology
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Chronic Disease
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Electroencephalography
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Evoked Potentials, Somatosensory
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Follow-Up Studies
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Humans
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Hypnotics and Sedatives / poisoning*
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Magnetic Resonance Imaging
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Male
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Peripheral Nervous System Diseases / chemically induced*
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Peripheral Nervous System Diseases / diagnosis
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Peripheral Nervous System Diseases / physiopathology
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Sural Nerve / drug effects
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Sural Nerve / physiopathology
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Sural Nerve / ultrastructure
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Tegmentum Mesencephali / drug effects
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Tegmentum Mesencephali / pathology
Substances
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Hypnotics and Sedatives
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Bromisovalum