Abstract
The MAM-subfamily of type II transmembrane protein tyrosine phosphatases (PTPases) currently comprises the enzymes PTPkappa, PTPmu and PCP2. In an effort to elucidate the individual physiological roles of these closely related proteins we performed a detailed analysis of their mRNA transcript distributions at different stages of mouse embryogenesis and postnatal brain development. Our in situ hybridization studies revealed distinct and complementary expression patterns of PTPkappa, PTPmu and PCP2 transcripts. Based on our results and previous reports we discuss MAM-PTPases as a new class of morphoregulatory molecules.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / embryology
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Brain / growth & development
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DNA, Complementary / genetics
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Embryonic and Fetal Development / genetics
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Gene Expression Regulation, Developmental*
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Protein Tyrosine Phosphatases / classification
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Protein Tyrosine Phosphatases / genetics*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptor Protein-Tyrosine Kinases / genetics
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Receptors, Growth Factor / genetics
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Receptors, Vascular Endothelial Growth Factor
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Tissue Distribution
Substances
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DNA, Complementary
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RNA, Messenger
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Receptors, Growth Factor
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Receptor Protein-Tyrosine Kinases
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Receptors, Vascular Endothelial Growth Factor
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Protein Tyrosine Phosphatases