Identification and characterization of a novel member of the dystrobrevin gene family

FEBS Lett. 1998 Mar 20;425(1):7-13. doi: 10.1016/s0014-5793(98)00097-0.

Abstract

A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Blotting, Western
  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 2
  • DNA, Complementary
  • Dystrophin-Associated Proteins*
  • Heterozygote
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Muscle, Skeletal / metabolism
  • Muscular Dystrophies / genetics
  • Neuropeptides / genetics*
  • RNA Splicing
  • Rabbits
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured

Substances

  • DNA, Complementary
  • DTNB protein, human
  • Dystrophin-Associated Proteins
  • Neuropeptides

Associated data

  • GENBANK/Y12712
  • GENBANK/Y15718
  • GENBANK/Y15719
  • GENBANK/Y15720
  • GENBANK/Y15721
  • GENBANK/Y15722
  • GENBANK/Y15742