Antigenic homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin beta3)

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):385-90. doi: 10.1097/00042560-199804150-00001.

Abstract

Fifty-eight of 89 serum samples (65.17%) from HIV-1-infected individuals at various disease stages contain antibodies that react with a platelet peptide located in the cytoplasmic domain of integrin beta3, glycoprotein GPIIIa (aa749-761; sequence DRKEFAKFEEERA). Rabbit polyclonal antibodies raised against the synthetic platelet peptide also react with the structurally homologous HIV-1 gp41-derived peptide (EKNEQELLELDKW(A)) and bind to a Western blot band with molecular weight corresponding to HIV-1 gp41. These findings point to molecular mimicry between HIV-1 and a human membrane protein found in platelets and other cells that could be of pathologic consequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Helminth / immunology
  • Antigens, CD / chemistry
  • Antigens, CD / genetics*
  • Antigens, CD / immunology
  • Antigens, Helminth / chemistry
  • Antigens, Helminth / immunology
  • Blotting, Western
  • Cysticercosis / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / chemistry
  • Epitopes / genetics
  • Epitopes / immunology
  • HIV Antibodies / blood
  • HIV Antibodies / immunology
  • HIV Envelope Protein gp41 / chemistry
  • HIV Envelope Protein gp41 / genetics*
  • HIV Envelope Protein gp41 / immunology
  • HIV Infections / blood
  • HIV Infections / immunology
  • HIV Seropositivity / immunology
  • HIV-1 / chemistry
  • HIV-1 / genetics
  • HIV-1 / immunology
  • Helminth Proteins / immunology
  • Humans
  • Immune Sera / immunology
  • Integrin beta3
  • Molecular Sequence Data
  • Oligopeptides / chemical synthesis
  • Oligopeptides / immunology
  • Peptides / chemistry
  • Peptides / immunology
  • Platelet Count
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / genetics*
  • Platelet Membrane Glycoproteins / immunology
  • Rabbits
  • Sequence Homology, Amino Acid
  • Serologic Tests

Substances

  • Antibodies, Helminth
  • Antigens, CD
  • Antigens, Helminth
  • Epitopes
  • HIV Antibodies
  • HIV Envelope Protein gp41
  • Helminth Proteins
  • Immune Sera
  • Integrin beta3
  • Oligopeptides
  • Peptides
  • Platelet Membrane Glycoproteins