Abstract
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Brain / metabolism
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Caudate Nucleus / metabolism
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Chromatography, Agarose
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Electron Probe Microanalysis
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Ferritins / analysis*
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Ferritins / metabolism
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Ferritins / ultrastructure
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Humans
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Immunoblotting
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Immunohistochemistry
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Microscopy, Electron
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Microscopy, Immunoelectron
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Supranuclear Palsy, Progressive / metabolism
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Supranuclear Palsy, Progressive / pathology*
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tau Proteins / analysis*
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tau Proteins / metabolism
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tau Proteins / ultrastructure