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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase.
Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T. Terauchi Y, et al. Nat Genet. 1999 Feb;21(2):230-5. doi: 10.1038/6023. Nat Genet. 1999. PMID: 9988280
PI3-kinase mutation linked to insulin and growth factor resistance in vivo.
Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. Winnay JN, et al. J Clin Invest. 2016 Apr 1;126(4):1401-12. doi: 10.1172/JCI84005. Epub 2016 Mar 14. J Clin Invest. 2016. PMID: 26974159 Free PMC article.