The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Science. 2016.
PMID: 27856912
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three dna methyltransferase DNMT3C protects male germ cells from transposon activity
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The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.
Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Hérault Y, Guillou F, Bourc'his D.
Barau J, et al.
Science. 2016 Nov 18;354(6314):909-912. doi: 10.1126/science.aah5143.
Science. 2016.
PMID: 27856912
Here, we describe the discovery of Dnmt3C, a de novo DNA methyltransferase gene that evolved via a duplication of Dnmt3B in rodent genomes and was previously annotated as a pseudogene. We show that DNMT3C is the enzyme responsible for methylating the p …
Here, we describe the discovery of Dnmt3C, a de novo DNA methyltransferase gene that evolved via a duplication of Dnmt3 …
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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.
Zoch A, Konieczny G, Auchynnikava T, Stallmeyer B, Rotte N, Heep M, Berrens RV, Schito M, Kabayama Y, Schöpp T, Kliesch S, Houston B, Nagirnaja L, O'Bryan MK, Aston KI, Conrad DF, Rappsilber J, Allshire RC, Cook AG, Tüttelmann F, O'Carroll D.
Zoch A, et al.
Mol Cell. 2024 Mar 21;84(6):1021-1035.e11. doi: 10.1016/j.molcel.2024.01.014. Epub 2024 Feb 14.
Mol Cell. 2024.
PMID: 38359823
Free article.
In the male mouse germ line, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide DNA methylation of young active transposons through SPOCD1. ...DNMT3C, the DNA methyltransferase responsible for …
In the male mouse germ line, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide DNA methyl …
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