An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.
Sheline YI, West T, Yarasheski K, Swarm R, Jasielec MS, Fisher JR, Ficker WD, Yan P, Xiong C, Frederiksen C, Grzelak MV, Chott R, Bateman RJ, Morris JC, Mintun MA, Lee JM, Cirrito JR.
Sheline YI, et al.
Sci Transl Med. 2014 May 14;6(236):236re4. doi: 10.1126/scitranslmed.3008169.
Sci Transl Med. 2014.
PMID: 24828079
Free PMC article.
Clinical Trial.
Serotonin signaling suppresses generation of amyloid-beta (Abeta) in vitro and in animal models of Alzheimer's disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective ser …
Serotonin signaling suppresses generation of amyloid-beta (Abeta) in vitro and in animal models of Alzheimer's disease …