PubMed for id: 411051

Year	Number of Results
1993	1
1994	3
1995	1
1997	1
1998	5
2000	1
2002	1
2003	1
2009	1
2013	1
2014	3
2015	2
2016	3
2017	1
2024	0

1

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease.

Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Zhang Z, et al. Nat Struct Mol Biol. 2017 Aug;24(8):632-642. doi: 10.1038/nsmb.3433. Epub 2017 Jul 3. Nat Struct Mol Biol. 2017. PMID: 28671665 Free PMC article.

2

Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway.

Zhu W, Shao Y, Yang M, Jia M, Peng Y. Zhu W, et al. Gene. 2016 Dec 15;594(2):176-182. doi: 10.1016/j.gene.2016.08.049. Epub 2016 Aug 30. Gene. 2016. PMID: 27590439

3

Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW. Edgington-Mitchell LE, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27514475 Free PMC article.

4

Prognostic value of legumain in uveal melanoma.

Wu T, Sun L, Wu Y, Xiang R, Li Y, Rong W, Sun F, Wang N. Wu T, et al. Mol Med Rep. 2016 Mar;13(3):2377-84. doi: 10.3892/mmr.2016.4838. Epub 2016 Jan 29. Mol Med Rep. 2016. PMID: 26846877 Free PMC article.

5

Clinicopathologic significance of legumain overexpression in cancer: a systematic review and meta-analysis.

Zhen Y, Chunlei G, Wenzhi S, Shuangtao Z, Na L, Rongrong W, Xiaohe L, Haiying N, Dehong L, Shan J, Xiaoyue T, Rong X. Zhen Y, et al. Sci Rep. 2015 Nov 26;5:16599. doi: 10.1038/srep16599. Sci Rep. 2015. PMID: 26607955 Free PMC article. Review.

6

Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells.

Yamane T, Yamamoto Y, Nakano Y, Nakagaki T, Ohkubo I, Ariga H. Yamane T, et al. Biochem Biophys Res Commun. 2015 Nov 20;467(3):472-7. doi: 10.1016/j.bbrc.2015.10.032. Epub 2015 Oct 14. Biochem Biophys Res Commun. 2015. PMID: 26462467

7

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

Zhang Z, Song M, Liu X, Kang SS, Kwon IS, Duong DM, Seyfried NT, Hu WT, Liu Z, Wang JZ, Cheng L, Sun YE, Yu SP, Levey AI, Ye K. Zhang Z, et al. Nat Med. 2014 Nov;20(11):1254-62. doi: 10.1038/nm.3700. Epub 2014 Oct 19. Nat Med. 2014. PMID: 25326800 Free PMC article.

8

The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.

Ma L, Shen YQ, Khatri HP, Schachner M. Ma L, et al. PLoS One. 2014 Apr 18;9(4):e95098. doi: 10.1371/journal.pone.0095098. eCollection 2014. PLoS One. 2014. PMID: 24747977 Free PMC article.

9

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.

Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu ZJ. Zhao L, et al. Cell Res. 2014 Mar;24(3):344-58. doi: 10.1038/cr.2014.4. Epub 2014 Jan 10. Cell Res. 2014. PMID: 24407422 Free PMC article.

10

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation.

Dall E, Brandstetter H. Dall E, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10940-5. doi: 10.1073/pnas.1300686110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776206 Free PMC article.

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