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38374466,38355793,38267530,38102300,38096054,38040383,37996924,37894844,37827155,37726802,37688357,37684045,37664244,37539389,37479809,37446179,37431882,37187609,36967065,36914640,36867535,36776123,36670467,36650127,36640336,36574405,36508327,36278490,36265442,36044862,36044851,36029989,35943803,35366418,35238684,35086928,34888656,34884918,34884469,34880223,34793694,34648564,34504195,34469738,34390831,34341363,34331233,34239412,34233199,34151850,34128157,34043007,34011527,33940179,33907289,33674575,33618800,33601422,33556538,33441541,33370315,33335120,33238365,33170804,33113354,33086039,32990597,32984817,32933349,32913184,32897880,32876667,32869871,32859226,32821928,32820193,32747555,32681824,32681165,32640230,32581130,32574176,32513388,32452382,32444599,32436947,32325033,32242231,32144144,32093570,32004439,31968243,31920562,31913581,31912442,31875875,31816043,31790427,31695145,31677786,31666698,31666200,31499139,31418857,31379510,31375685,31282030,31263285,31184975,31132785,31109380,31068790,31060804,31040226,31017573,31015293,30961637,30930170,30914652,30913220,30897080,30819797,30742117,30626701,30624705,30587542,30517854,30451892,30449600,30391555,30365550,30333735,30333137,30323233,30321100,30312396,30282695,30262848,30239724,30193095,30182387,30179155,30118496,30061661,30054496,29967375,29912367,29894684,29891550,29843246,29789657,29694882,29688337,29617656,29534157,29460266,29430620,29396492,29355642,29324753,29302618,29298414,29274742,29259100,29212017,29162692,28993428,28986324,28970536,28930690,28927719,28893927,28847953,28823953,28743452,28729730,28715425,28676743,28653853,28628038,28578004,28555636,28550168,28502806,28469074,28453524,28396396,28391067,28384479,28384474,28334820,28211815,28194040,28175299,28171658,28104789,28099507,28069792,28031289,28017473,28007908,27995895,27989734,27988204,27916455,27913616,27886014,27721240,27701442,27646506,27639545,27623015,27615381,27601642,27570076,27568644,27561680,27559163,27525439,27516062,27493027,27486903,27484239,27466181,27463137,27405468,27381424,27378694,27334347,27322419,27219491,27217211,27203582,27199664,27196694,27170174,27163546,27147652,27147650,27140644,27063456,27008868,26951659,26947127,26908614,26908605,26908599,26900923,26859386,26793080,26681807,26660732,26659666,26634350,26546830,26464486,26464483,26419281,26362846,26295712,26293574,26282324,26247199,26210937,26195796,26165689,26143143,26141599,26048156,26037141,25989602,25942483,25914140,25866151,25859666,25789755,25762686,25760041,25748626,25747711,25738228,25686248,25661181,25645993,25619660,25609071,25574027,25540325,25526803,25478910,25461618,25449908,25447230,25446099,25411494,25398949,25368120,25205111,25205109,25180603,25143394,25101683,25062858,25057205,25035419,25009276,25004085,24992836,24991961,24960609,24955833,24951540,24948797,24946181,24906892,24780625,24749073,24728353,24728190,24706802,24706768,24696705,24619418,24594939,24453320,24376631,24347167,24302884,24282028,24278347,24204315,24116161,24105466,24086450,24040016,24021477,24019939,23969239,23967334,23936129,23925262,23908352,23861892,23852340,23829302,23774650,23691206,23678106,23652004,23598407,23572526,23525043,23469253,23374344,23372043,23365139,23352662,23341638,23341618,23300147,23284644,23284626,23251447,23230231,23219902,23209424,23197653,23195593,23145961,23122961,23054839,23012356,23001568,22984513,22970194,22956985,22956852,22939619,22892315,22891683,22822065,22794259,22649566,22589249,22579526,22556411,22542623,22529362,22512000,22511757,22508027,22492998,22466506,22396390,22365050,22355657,22341442,22337954,22327034,22216210,22191580,22178857,22123826,22123819,22116937,22085744,22044764,22041125,22011578,22001697,21994396,21985783,21969577,21954231,21897851,21896309,21873635,21840924,21832090,21785217,21768291,21677750,21636527,21632937,21542802,21536587,21513775,21511013,21505144,21482444,21459327,21454633,21454471,21447599,21440047,21403395,21364626,21347256,21336284,21315254,21304966,21267068,21248135,21245084,21192926,21184755,21179468,21106706,20945165,20739295,20696378,20668203,20616151,20531388,20519964,20497470,20494921,20457230,20457229,20444706,20442398,20403078,20383138,20357106,20354076,20185826,20185558,20140187,20086007,20064390,20053912,20018729,19997493,19956633,19955426,19933700,19915593,19825844,19745829,19710014,19692612,19666572,19646509,19642201,19602103,19566678,19525941,19498170,19488402,19487684,19464370,19445966,19345187,19279257,19264961,19240112,19240033,19144827,19124532,19074039,19036965,18981372,18923047,18845944,18838463,18829967,18805465,18799693,18768691,18669659,18640979,18625748,18625318,18615096,18602275,18595722,18558632,18504298,18502655,18412970,18367261,18337408,18299573,18288205,18242663,18065495,17947312,17868456,17715336,17708681,17704510,17611284,17548833,17519223,17500595,17442827,17394466,17352931,17335925,17334227,17291464,17284197,17239451,17213233,17208201,17147801,17124493,17114649,17065224,17055784,17018277,17012230,16978870,16820007,16777606,16766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Results by year

Year	Number of Results
1992	1
1993	1
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2024	4

723 results

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Page 1

Lowering mutant huntingtin by small molecules relieves Huntington's disease symptoms and progression.

Bahat A, Itzhaki E, Weiss B, Tolmasov M, Tsoory M, Kuperman Y, Brandis A, Shurrush KA, Dikstein R. Bahat A, et al. EMBO Mol Med. 2024 Mar;16(3):523-546. doi: 10.1038/s44321-023-00020-y. Epub 2024 Feb 19. EMBO Mol Med. 2024. PMID: 38374466 Free PMC article.

Genetic determinants of micronucleus formation in vivo.

Adams DJ, Barlas B, McIntyre RE, Salguero I, van der Weyden L, Barros A, Vicente JR, Karimpour N, Haider A, Ranzani M, Turner G, Thompson NA, Harle V, Olvera-León R, Robles-Espinoza CD, Speak AO, Geisler N, Weninger WJ, Geyer SH, Hewinson J, Karp NA; Sanger Mouse Genetics Project; Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten MS, Rowland BD, Lelliott CJ, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen AG, Rooimans MA, de Lange J, Mohun TJ, Arends MJ, Kentistou KA, Coelho PA, Zhao Y, Zecchini H, Perry JRB, Jackson SP, Balmus G. Adams DJ, et al. Nature. 2024 Mar;627(8002):130-136. doi: 10.1038/s41586-023-07009-0. Epub 2024 Feb 14. Nature. 2024. PMID: 38355793 Free PMC article.

Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.

Driscoll R, Hampton L, Abraham NA, Larigan JD, Joseph NF, Hernandez-Vega JC, Geisler S, Yang FC, Deninger M, Tran DT, Khatri N, Godinho BMDC, Kinberger GA, Montagna DR, Hirst WD, Guardado CL, Glajch KE, Arnold HM, Gallant-Behm CL, Weihofen A. Driscoll R, et al. Sci Rep. 2024 Jan 24;14(1):2061. doi: 10.1038/s41598-024-52667-3. Sci Rep. 2024. PMID: 38267530 Free PMC article.

Elucidation of Site-Specific Ubiquitination on Chaperones in Response to Mutant Huntingtin.

Panda P, Sarohi V, Basak T, Kasturi P. Panda P, et al. Cell Mol Neurobiol. 2023 Dec 15;44(1):3. doi: 10.1007/s10571-023-01446-1. Cell Mol Neurobiol. 2023. PMID: 38102300

Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington's disease.

Chen JH, Xu N, Qi L, Yan HH, Wan FY, Gao F, Fu C, Cang C, Lu B, Bi GQ, Tang AH. Chen JH, et al. Cell Rep. 2023 Dec 26;42(12):113573. doi: 10.1016/j.celrep.2023.113573. Epub 2023 Dec 12. Cell Rep. 2023. PMID: 38096054 Free article.

Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.

Kuijper EC, Overzier M, Suidgeest E, Dzyubachyk O, Maguin C, Pérot JB, Flament J, Ariyurek Y, Mei H, Buijsen RAM, van der Weerd L, van Roon-Mom W. Kuijper EC, et al. Neurobiol Dis. 2024 Jan;190:106368. doi: 10.1016/j.nbd.2023.106368. Epub 2023 Nov 29. Neurobiol Dis. 2024. PMID: 38040383 Free article.

Naïve Huntington's disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1.

Steinberg N, Galleguillos D, Zaidi A, Horkey M, Sipione S. Steinberg N, et al. J Neuroinflammation. 2023 Nov 23;20(1):276. doi: 10.1186/s12974-023-02963-y. J Neuroinflammation. 2023. PMID: 37996924 Free PMC article.

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington's Disease Progression in Male zQ175 Transgenic Mice.

Merino M, González S, Tronch MC, Sánchez-Sánchez AV, Clares MP, García-España A, García-España E, Mullor JL. Merino M, et al. Int J Mol Sci. 2023 Oct 13;24(20):15153. doi: 10.3390/ijms242015153. Int J Mol Sci. 2023. PMID: 37894844 Free PMC article.

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.

Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE. Gall-Duncan T, et al. Cell. 2023 Oct 26;186(22):4898-4919.e25. doi: 10.1016/j.cell.2023.09.008. Epub 2023 Oct 11. Cell. 2023. PMID: 37827155

Comparison of Huntington's disease phenotype progression in male and female heterozygous FDNQ175 mice.

Li SH, Colson TL, Chen J, Abd-Elrahman KS, Ferguson SSG. Li SH, et al. Mol Brain. 2023 Sep 19;16(1):67. doi: 10.1186/s13041-023-01054-6. Mol Brain. 2023. PMID: 37726802 Free PMC article.

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