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2,265 results

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Page 1

Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.

Castiello MC, Brandas C, Ferrari S, Porcellini S, Sacchetti N, Canarutto D, Draghici E, Merelli I, Barcella M, Pelosi G, Vavassori V, Varesi A, Jacob A, Scala S, Basso Ricci L, Paulis M, Strina D, Di Verniere M, Sergi Sergi L, Serafini M, Holland SM, Bergerson JRE, De Ravin SS, Malech HL, Pala F, Bosticardo M, Brombin C, Cugnata F, Calzoni E, Crooks GM, Notarangelo LD, Genovese P, Naldini L, Villa A. Castiello MC, et al. Sci Transl Med. 2024 Feb 7;16(733):eadh8162. doi: 10.1126/scitranslmed.adh8162. Epub 2024 Feb 7. Sci Transl Med. 2024. PMID: 38324638

Rag1 Deficiency Impairs Arteriogenesis in Mice.

Kumaraswami K, Arnholdt C, Deindl E, Lasch M. Kumaraswami K, et al. Int J Mol Sci. 2023 Aug 16;24(16):12839. doi: 10.3390/ijms241612839. Int J Mol Sci. 2023. PMID: 37629019 Free PMC article.

Transplantation elicits a clonally diverse CD8⁺ T cell response that is comprised of potent CD43⁺ effectors.

Cohen GS, Kallarakal MA, Jayaraman S, Ibukun FI, Tong KP, Orzolek LD, Larman HB, Krummey SM. Cohen GS, et al. Cell Rep. 2023 Aug 29;42(8):112993. doi: 10.1016/j.celrep.2023.112993. Epub 2023 Aug 16. Cell Rep. 2023. PMID: 37590141 Free PMC article.

Lower female survival from an opportunistic infection reveals progesterone-driven sex bias in trained immunity.

Earhart AP, Karasseva NG, Storey KM, Olthoff B, Sarker MB, Laffey KG, Lange MJ, Rector RS, Schulz LC, Gil D, Neuhauser CM, Schrum AG. Earhart AP, et al. Cell Rep. 2023 Aug 29;42(8):113007. doi: 10.1016/j.celrep.2023.113007. Epub 2023 Aug 16. Cell Rep. 2023. PMID: 37590139 Free PMC article.

An ocular Th1 immune response promotes corneal nerve damage independently of the development of corneal epitheliopathy.

Vereertbrugghen A, Pizzano M, Sabbione F, Keitelman IA, Shiromizu CM, Aguilar DV, Fuentes F, de Paiva CS, Giordano M, Trevani A, Galletti JG. Vereertbrugghen A, et al. J Neuroinflammation. 2023 May 22;20(1):120. doi: 10.1186/s12974-023-02800-2. J Neuroinflammation. 2023. PMID: 37217914 Free PMC article.

T cells modulate the microglial response to brain ischemia.

Benakis C, Simats A, Tritschler S, Heindl S, Besson-Girard S, Llovera G, Pinkham K, Kolz A, Ricci A, Theis FJ, Bittner S, Gökce Ö, Peters A, Liesz A. Benakis C, et al. Elife. 2022 Dec 13;11:e82031. doi: 10.7554/eLife.82031. Elife. 2022. PMID: 36512388 Free PMC article.

Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage.

Chen J, Li R, Knapp S, Zhu G, Whitener RL, Leiter EH, Mathews CE. Chen J, et al. Front Genet. 2022 Oct 7;13:994501. doi: 10.3389/fgene.2022.994501. eCollection 2022. Front Genet. 2022. PMID: 36276935 Free PMC article.

Immune responses in mice after blast-mediated traumatic brain injury TBI autonomously contribute to retinal ganglion cell dysfunction and death.

Harper MM, Gramlich OW, Elwood BW, Boehme NA, Dutca LM, Kuehn MH. Harper MM, et al. Exp Eye Res. 2022 Dec;225:109272. doi: 10.1016/j.exer.2022.109272. Epub 2022 Oct 6. Exp Eye Res. 2022. PMID: 36209837

Genetically diverse mouse platform to xenograft cancer cells.

Sargent JK, Warner MA, Low BE, Schott WH, Hoffert T, Coleman D, Woo XY, Sheridan T, Erattupuzha S, Henrich PP, Philip VM, Chuang JH, Wiles MV, Hasham MG. Sargent JK, et al. Dis Model Mech. 2022 Sep 1;15(9):dmm049457. doi: 10.1242/dmm.049457. Epub 2022 Aug 29. Dis Model Mech. 2022. PMID: 36037073 Free PMC article.

The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages.

Burn TN, Miot C, Gordon SM, Culberson EJ, Diamond T, Kreiger PA, Hayer KE, Bhattacharyya A, Jones JM, Bassing CH, Behrens EM. Burn TN, et al. J Immunol. 2022 Sep 1;209(5):938-949. doi: 10.4049/jimmunol.2001441. Epub 2022 Aug 10. J Immunol. 2022. PMID: 35948399 Free PMC article.

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