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36208091,36113988,35924411,35487642,34837403,34761252,34203177,34108644,34059744,33886538,33837488,33526988,33357406,33244609,33242073,32940945,32902747,32373223,31666131,31433521,31248416,31029155,30806579,30710526,30448460,29874113,28974240,28790115,28785832,28779004,28422960,28256262,28004223,27258499,27069191,26975740,26951660,26498247,26077460,26025730,25640028,25490383,25410477,25175513,25134804,24933000,24530475,24501230,24212987,24039744,23376256,23170986,22781090,22775459,22739024,22433851,22386861,22188021,22086974,21946537,21926548,21821902,21778331,21732224,21538690,21419771,21419447,21360204,21354521,21309037,21156417,21047769,20931542,20672385,20505253,20438357,20388775,20095990,19911012,19818066,19759184,19669601,19639020,19582509,19418671,19390556,19228687,19160096,18955159,18951462,18822302,18781619,18781192,18761787,18674656,18635600,18567801,18470917,18406877,18381419,18335504,18270343,18186537,18181177,17982623,17922223,17894833,17661183,17611581,17601929,17582678,17566596,17531106,17414604,17407090,17351251,17333219,17250661,17165155,17139886,17051350,17039271,16918138,16451135,16199548,16086322,15527911,15503820,15467751,15063132,15015769,14580774,14499697,12912950,12810667,12792735,12694232,12688322,12658575,12610360,12595050,12549480,12454801,12391284,12203789,12124176,11890986,11859209,11857301,11809679,11531323,10978353,10874318,10850409,10693791,10612836,10528862,10051005,10023327,9843200,9777949,9709044,9621522,9240418,9217825,9060003,9024626,8769132,8723682,8700523,8690195,8484120,8168125,8156592,8062247,8036718,7973733,7874129,7726159,7585562,4016686,37919876,37914149,37657688,37392283,36994850,36894311,36291559,35897048,35608067,35279875,34879271,33958709,33901323,33874956,33640455,33615670,33414469,33191490,32756484,32749112,31939059,31494577,31373852,31273068,30803214,30486602,30481381,30149959,29715107,29575718,29342268,29025352,28667494,28537674,28525661,27805738,27783137,27665274,27466510,27459116,27036951,26975374,26728996,26477961,26446363,26381082,26053027,25804231,25560462,25255306,25216868,25200962,25155585,25107687,25106712,24874052,24793746,24395779,24360395,24333619,24317816,24122742,24078570,24073290,23990280,23865379,23573243,23526924,23485110,23391514,23329266,23301373,23255516,23231927,23149851,23045530,22865300,22806311,22635031,22581703,22453149,22378480,22371642,22277660,22265839,22234160,22219001,22188959,22179786,22173703,22164234,22067334,21988782,21960445,21937421,21937259,21766496,21744313,21681552,21660619,21615986,21513149,21431882,21286667,21155023,21128252,21122410,21091774,21078976,21070872,21034533,20872076,20846263,20373145,20332274,20305446,20210238,20090515,20072951,20064472,19950599,19930554,19893772,19760518,19734583,19728162,19720893,19697156,19685281,19669161,19621725,19621678,19525234,19486659,19464205,19423266,19419416,19267393,19237577,19207881,19100506,19098912,19034977,19032668,18931482,18787700,18772310,18726168,18713544,18708397,18646042,18629513,18581137,18561205,18547406,18543228,18514060,18393252,18331286,18325052,18299982,18289827,18265677,18265645,18202787,17987798,17942459,17939062,17711772,17652529,17569143,17531815,17505997,17483304,17473388,17350822,17275176,17228328,17219447,17160686,17109103,17039269,17011982,16995940,16985024,16940983,16908935,16874859,16810763,16786121,16773692,16696788,16684085,16614121,16569647,16541406,16500024,16341550,16331552,16252083,16234028,16143124,16061855,16025128,16012876,16003840,15996210,15904475,15862756,15858146,15832775,15831578,15786548,15774782,15735976,15713769,15696491,15596632,15467433,15365996,15350299,15342696,15340264,15309712,15241839,15216397,15200905,15161053,15062061,15043999,15043284,15042510,14760534,14716824,14714570,14635101,14631366,14574163,14562278,14529665,14526391,14500385,12938096,12930688,12920342,12817878,12808326,12712438,12697969,12684691,12660027,12632492,12627520,12622604,12522549,12494471,12101417,12095971,11920650,11920468,11910346,11879922,11857745,11782355,11748856,11726306,11606497,11579115,11562928,11208710,11104559,10777691,10713887,10469597,9718327,9677427,9559627,9490293,9428522,9311737,9298827,9259192,9111864,9087566,9048925,8993976,8872463,8805365,8797773,8566964,8261515,7923193,7604264,7585546,37314251,36434146,33619096,32586954,32448028,32363617,32325698,32002723,31964471,31926173,31843968,31662440,30723092,30686591,30238922,28772289,28705114,28651545,28376765,28176205,27836416,27693945,27546332,27468915,27261338,27013479,26842232,26215063,26088318,25664706,25639900,25133505,24366688,24185125,24090359,23904372,23817394,23794306,22941650,22883484,22776989,22456432,22331944,22287095,22017238,21706233,21642682,21358597,21348638,21093954,21056691,21029181,20937110,20591884,20495877,20458443,20206180,20160730,20154325,20056646,20028567,19900449,19861671,19741564,19723918,19635727,19622357,19377479,19291797,19254532,19215248,19075283,19062740,18972272,18949393,18624996,18623088,18566915,18554281,18326858,18257912,18061181,18033691,17785078,17454882,17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Year	Number of Results
1985	1
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908 results

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High MutS homolog 2 expression predicts poor prognosis and is related to immune infiltration in endometrial carcinoma.

Lu X, Ying Y, Zhang W, Li R, Zhang J. Lu X, et al. Cell Biol Int. 2023 Jan;47(1):201-215. doi: 10.1002/cbin.11925. Epub 2022 Oct 8. Cell Biol Int. 2023. PMID: 36208091

Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 variants causing in-frame splicing alterations.

Meulemans L, Baert Desurmont S, Waill MC, Castelain G, Killian A, Hauchard J, Frebourg T, Coulet F, Martins A, Muleris M, Gaildrat P. Meulemans L, et al. J Med Genet. 2023 May;60(5):450-459. doi: 10.1136/jmg-2022-108576. Epub 2022 Sep 16. J Med Genet. 2023. PMID: 36113988

Genetic polymorphisms in the mismatch repair pathway (MMR) genes contribute to hematological and gastrointestinal toxicity in North Indian lung cancer patients treated with platinum-based chemotherapy.

Singh S, Singh N, Sharma S. Singh S, et al. J Biochem Mol Toxicol. 2022 Nov;36(11):e23183. doi: 10.1002/jbt.23183. Epub 2022 Aug 4. J Biochem Mol Toxicol. 2022. PMID: 35924411

RNA sequencing uncovers clinically actionable germline intronic MSH2 variants in previously unresolved Lynch syndrome families.

Fulk K, Turner M, Eppolito A, Krukenberg R. Fulk K, et al. BMJ Case Rep. 2022 Apr 29;15(4):e249580. doi: 10.1136/bcr-2022-249580. BMJ Case Rep. 2022. PMID: 35487642

Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein.

Singh S, Sharma S, Baranwal M. Singh S, et al. Biotechnol Appl Biochem. 2022 Dec;69(6):2454-2465. doi: 10.1002/bab.2295. Epub 2021 Dec 15. Biotechnol Appl Biochem. 2022. PMID: 34837403

A novel Lynch syndrome pedigree bearing germ-line MSH2 missense mutation c.1808A>T (Asp603Val).

Sekine R, Shimazu K, Nakano D, Yamaguchi T, Suzuki Y, Fukuda K, Yoshida T, Taguchi D, Iijima K, Nanjyo H, Shibata H. Sekine R, et al. Jpn J Clin Oncol. 2022 Jan 3;52(1):81-85. doi: 10.1093/jjco/hyab173. Jpn J Clin Oncol. 2022. PMID: 34761252

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study.

Dominguez-Valentin M, Plazzer JP, Sampson JR, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Macrae F, Winship IM, Thomas H, Evans DG, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Sijmons RH, Nielsen M, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Lindblom A, Valle AD, Lopez-Kostner F, Alvarez K, Gluck N, Katz L, Heinimann K, Vaccaro CA, Nakken S, Hovig E, Green K, Lalloo F, Hill J, Vasen HFA, Perne C, Büttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M, Rahner N, Weitz J, Steinke-Lange V, Schmiegel W, Vangala D, Crosbie EJ, Pineda M, Navarro M, Brunet J, Moreira L, Sánchez A, Serra-Burriel M, Mints M, Kariv R, Rosner G, Piñero TA, Pavicic WH, Kalfayan P, Broeke SWT, Mecklin JP, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Peltomäki P, Hopper JL, Win AK, Buchanan DD, Lindor NM, Gallinger S, Marchand LL, Newcomb PA, Figueiredo JC, Thibodeau SN, Therkildsen C, Hansen TVO, Lindberg L, Rødland EA, Neffa F, Esperon P, Tjandra D, Möslein G, Seppälä TT, Møller P. Dominguez-Valentin M, et al. J Clin Med. 2021 Jun 28;10(13):2856. doi: 10.3390/jcm10132856. J Clin Med. 2021. PMID: 34203177 Free PMC article.

MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer.

McCoy P, Mangiola S, Macintyre G, Hutchinson R, Tran B, Pope B, Georgeson P, Hong MKH, Kurganovs N, Lunke S, Clarkson MJ, Cmero M, Kerger M, Stuchbery R, Chow K, Haviv I, Ryan A, Costello AJ, Corcoran NM, Hovens CM. McCoy P, et al. Prostate Cancer Prostatic Dis. 2021 Dec;24(4):1167-1180. doi: 10.1038/s41391-021-00379-4. Epub 2021 Jun 9. Prostate Cancer Prostatic Dis. 2021. PMID: 34108644

A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants.

Wiik MU, Evans TJ, Belhadj S, Bolton KA, Dymerska D, Jagmohan-Changur S, Capellá G, Kurzawski G, Wijnen JT, Valle L, Vasen HFA, Lubinski J, Scott RJ, Talseth-Palmer BA. Wiik MU, et al. Sci Rep. 2021 May 31;11(1):11401. doi: 10.1038/s41598-021-90501-2. Sci Rep. 2021. PMID: 34059744 Free PMC article.

Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition.

Nielsen SV, Hartmann-Petersen R, Stein A, Lindorff-Larsen K. Nielsen SV, et al. PLoS Genet. 2021 Apr 22;17(4):e1009496. doi: 10.1371/journal.pgen.1009496. eCollection 2021 Apr. PLoS Genet. 2021. PMID: 33886538 Free PMC article. No abstract available.

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