PubMed (GeneRIF) for id: 116986

Year	Number of Results
2003	1
2004	1
2005	3
2006	2
2007	5
2008	4
2009	2
2010	1
2011	2
2012	2
2013	3
2015	3
2016	2
2017	2
2019	3
2021	1
2024	0

1

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.

Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S, Shan C, Zhang S. Sun M, et al. Biochem Pharmacol. 2021 Oct;192:114736. doi: 10.1016/j.bcp.2021.114736. Epub 2021 Aug 16. Biochem Pharmacol. 2021. PMID: 34411567

2

Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.

Yu L, Gui S, Liu Y, Qiu X, Zhang G, Zhang X, Pan J, Fan J, Qi S, Qiu B. Yu L, et al. Aging (Albany NY). 2019 Aug 5;11(15):5300-5318. doi: 10.18632/aging.102092. Epub 2019 Aug 5. Aging (Albany NY). 2019. PMID: 31386624 Free PMC article.

3

SP1 and RARα regulate AGAP2 expression in cancer.

Doush Y, Surani AA, Navarro-Corcuera A, McArdle S, Billett EE, Montiel-Duarte C. Doush Y, et al. Sci Rep. 2019 Jan 23;9(1):390. doi: 10.1038/s41598-018-36888-x. Sci Rep. 2019. PMID: 30674964 Free PMC article.

4

Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells.

Navarro-Corcuera A, López-Zabalza MJ, Martínez-Irujo JJ, Álvarez-Sola G, Ávila MA, Iraburu MJ, Ansorena E, Montiel-Duarte C. Navarro-Corcuera A, et al. Biochim Biophys Acta Mol Cell Res. 2019 Apr;1866(4):673-685. doi: 10.1016/j.bbamcr.2019.01.008. Epub 2019 Jan 17. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30660615 Free article.

5

Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.

Qi Q, Kang SS, Zhang S, Pham C, Fu H, Brat DJ, Ye K. Qi Q, et al. Oncogene. 2017 Aug 10;36(32):4562-4572. doi: 10.1038/onc.2017.67. Epub 2017 Apr 3. Oncogene. 2017. PMID: 28368413 Free PMC article.

6

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

Kang SS, Zhang Z, Liu X, Manfredsson FP, He L, Iuvone PM, Cao X, Sun YE, Jin L, Ye K. Kang SS, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1183-1188. doi: 10.1073/pnas.1618627114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096359 Free PMC article.

7

Phosphoinositide-3-Kinase Enhancers, PIKEs: Their Biological Functions and Roles in Cancer.

Jia W, Feng YI, Sanders AJ, Davies EL, Jiang WG. Jia W, et al. Anticancer Res. 2016 Mar;36(3):1103-9. Anticancer Res. 2016. PMID: 26977005 Review.

8

Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.

Jiang Y, Liao L, Shrestha C, Ji S, Chen Y, Peng J, Wang L, Liao E, Xie Z. Jiang Y, et al. Int J Clin Exp Pathol. 2015 Aug 1;8(8):9042-51. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26464646 Free PMC article.

9

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.

Zhang S, Qi Q, Chan CB, Zhou W, Chen J, Luo HR, Appin C, Brat DJ, Ye K. Zhang S, et al. Cell Death Differ. 2016 Jan;23(1):52-63. doi: 10.1038/cdd.2015.66. Epub 2015 May 22. Cell Death Differ. 2016. PMID: 26001218 Free PMC article.

10

Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.

Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ. Gross C, et al. Cell Rep. 2015 May 5;11(5):727-36. doi: 10.1016/j.celrep.2015.03.060. Epub 2015 Apr 23. Cell Rep. 2015. PMID: 25921541 Free PMC article.

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