PubMed (GeneRIF) for id: 27346

Year	Number of Results
2004	1
2007	2
2010	1
2011	1
2012	2
2013	2
2014	1
2015	1
2016	3
2017	4
2018	2
2020	1
2021	3
2022	3
2023	1
2024	2

1

TMEM97 knockdown inhibits 5-fluorouracil resistance by regulating epithelial-mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathway in 5-fluorouracil-resistant colorectal cancer cells.

Xu Y, Tang Y, Xu Q, He W. Xu Y, et al. Chem Biol Drug Des. 2024 Feb;103(2):e14490. doi: 10.1111/cbdd.14490. Chem Biol Drug Des. 2024. PMID: 38388887

2

Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.

Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, Jackson RJ, Catterson JH, Spires-Jones MP, Rose J, Waybright L, Caggiano AO, King D, Gobbo F, Davies C, Hooley M, Dunnett S, Tempelaar R, Meftah S, Tzioras M, Hamby ME, Izzo NJ, Catalano SM, Durrant CS, Smith C, Dando O, Spires-Jones TL. Colom-Cadena M, et al. Acta Neuropathol. 2024 Feb 6;147(1):32. doi: 10.1007/s00401-023-02679-6. Acta Neuropathol. 2024. PMID: 38319380 Free PMC article.

3

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.

Thejer BM, Infantino V, Santarsiero A, Pappalardo I, Abatematteo FS, Teakel S, Van Oosterum A, Mach RH, Denora N, Lee BC, Resta N, Bagnulo R, Niso M, Contino M, Montsch B, Heffeter P, Abate C, Cahill MA. Thejer BM, et al. Int J Mol Sci. 2023 Mar 28;24(7):6381. doi: 10.3390/ijms24076381. Int J Mol Sci. 2023. PMID: 37047353 Free PMC article.

4

GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.

Ma D, Sun W, Fu C, Nazmi K, Veerman ECI, Jaspers RT, Bolscher JGM, Bikker FJ, Wu G. Ma D, et al. Int J Oral Sci. 2022 Aug 15;14(1):42. doi: 10.1038/s41368-022-00181-5. Int J Oral Sci. 2022. PMID: 35970844 Free PMC article.

5

TMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3β/β-catenin signaling pathway.

Mao D, Zhang X, Wang Z, Xu G, Zhang Y. Mao D, et al. Hum Cell. 2022 Sep;35(5):1535-1546. doi: 10.1007/s13577-022-00759-5. Epub 2022 Jul 30. Hum Cell. 2022. PMID: 35907137

6

Inhibition of MAC30 exerts antitumor effects in nasopharyngeal carcinoma via affecting the Akt/GSK-3β/β-catenin pathway.

Zhang P, Tian Q, Gao H, Zhao A, Shao Y, Yang J. Zhang P, et al. J Biochem Mol Toxicol. 2022 Jul;36(7):e23061. doi: 10.1002/jbt.23061. Epub 2022 Apr 4. J Biochem Mol Toxicol. 2022. PMID: 35373413

7

Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.

Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, Song J, Wang Z, Li H, Sun Q, Liu S, Sha O, Leng F, Chen X, Lu D. Zhu H, et al. Cell Death Dis. 2021 Oct 6;12(10):912. doi: 10.1038/s41419-021-04211-8. Cell Death Dis. 2021. PMID: 34615853 Free PMC article.

8

Histatin-1 is an endogenous ligand of the sigma-2 receptor.

Son KN, Lee H, Shah D, Kalmodia S, Miller RC, Ali M, Balasubramaniam A, Cologna SM, Kong H, Shukla D, Aakalu VK. Son KN, et al. FEBS J. 2021 Dec;288(23):6815-6827. doi: 10.1111/febs.16108. Epub 2021 Jul 23. FEBS J. 2021. PMID: 34233061 Free PMC article.

9

TMEM97 facilitates the activation of SOCE by downregulating the association of cholesterol to Orai1 in MDA-MB-231 cells.

Cantonero C, Camello PJ, Salido GM, Rosado JA, Redondo PC. Cantonero C, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jun;1866(6):158906. doi: 10.1016/j.bbalip.2021.158906. Epub 2021 Feb 20. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33618021

10

The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.

Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH. Riad A, et al. Mol Neurobiol. 2020 Sep;57(9):3803-3813. doi: 10.1007/s12035-020-01988-1. Epub 2020 Jun 23. Mol Neurobiol. 2020. PMID: 32572762 Free PMC article.

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