PubMed (GeneRIF) for id: 51295

Year	Number of Results
2007	1
2010	1
2012	1
2014	4
2015	3
2018	1
2019	1
2021	2
2023	1
2024	1

1

ECSIT facilitates memory CD8⁺ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.

Yang Y, Wang Y, Wang Z, Yan H, Gong Y, Hu Y, Jiang Y, Wen S, Xu F, Wang B, Humphries F, Chen Y, Wang X, Yang S. Yang Y, et al. Nat Cell Biol. 2024 Mar;26(3):450-463. doi: 10.1038/s41556-024-01351-9. Epub 2024 Feb 7. Nat Cell Biol. 2024. PMID: 38326554

2

ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.

Jiang Y, Ma C, Hu Y, Yang Y, Ma C, Wu C, Liu L, Wen S, Moynagh PN, Wang B, Yang S. Jiang Y, et al. Adv Sci (Weinh). 2023 Sep;10(25):e2205180. doi: 10.1002/advs.202205180. Epub 2023 Jul 6. Adv Sci (Weinh). 2023. PMID: 37409430 Free PMC article.

3

ECSIT is a critical limiting factor for cardiac function.

Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar KS, Hombrebueno JR, Stolz DB, Oleszycka E, Rodgers AM, Glezeva N, McDonald K, Watson CJ, Ledwidge MT, Ingram RJ, Grieve DJ, Moynagh PN. Xu L, et al. JCI Insight. 2021 Jun 22;6(12):e142801. doi: 10.1172/jci.insight.142801. JCI Insight. 2021. PMID: 34032637 Free PMC article.

4

No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma.

Ong SY, Lim JQ, Grigoropoulos N, Laurensia Y, Huang D, Chia BKH, Zhe DCM, Saraf SA, Cheng CL, Chuang WY, Kuo MC, Su YJ, Phipps C, Nagarajan C, Lee YS, Lung DTC, Shih LY, Goh YT, Lim ST, Ong CK. Ong SY, et al. Haematologica. 2021 Jun 1;106(6):1737-1739. doi: 10.3324/haematol.2020.269209. Haematologica. 2021. PMID: 33054138 Free PMC article. No abstract available.

5

CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.

Kim MJ, Min Y, Shim JH, Chun E, Lee KY. Kim MJ, et al. Front Immunol. 2019 Sep 18;10:2203. doi: 10.3389/fimmu.2019.02203. eCollection 2019. Front Immunol. 2019. PMID: 31620128 Free PMC article.

6

Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma.

Wen H, Ma H, Cai Q, Lin S, Lei X, He B, Wu S, Wang Z, Gao Y, Liu W, Liu W, Tao Q, Long Z, Yan M, Li D, Kelley KW, Yang Y, Huang H, Liu Q. Wen H, et al. Nat Med. 2018 Feb;24(2):154-164. doi: 10.1038/nm.4456. Epub 2018 Jan 1. Nat Med. 2018. PMID: 29291352

7

Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).

Chen WN, Liu LL, Jiao BY, Lin WS, Lin XJ, Lin X. Chen WN, et al. Virus Res. 2015 Jan 2;195:236-45. doi: 10.1016/j.virusres.2014.10.025. Epub 2014 Nov 1. Virus Res. 2015. PMID: 25449573

8

TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.

Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY. Wi SM, et al. J Biol Chem. 2014 Dec 19;289(51):35205-14. doi: 10.1074/jbc.M114.597187. Epub 2014 Nov 4. J Biol Chem. 2014. PMID: 25371197 Free PMC article.

9

Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.

Mi Wi S, Park J, Shim JH, Chun E, Lee KY. Mi Wi S, et al. Mol Biol Cell. 2015 Jan 1;26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29. Mol Biol Cell. 2015. PMID: 25355951 Free PMC article.

10

ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.

Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB. Lei CQ, et al. J Innate Immun. 2015;7(2):153-64. doi: 10.1159/000365971. Epub 2014 Sep 16. J Innate Immun. 2015. PMID: 25228397 Free PMC article.

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