PubMed (GeneRIF) for id: 55869

Year	Number of Results
2004	3
2005	1
2006	2
2007	2
2008	3
2009	5
2010	3
2011	3
2012	5
2013	7
2014	9
2015	12
2016	13
2017	10
2018	10
2019	13
2020	14
2021	5
2022	2
2023	6
2024	1

1

Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways.

Wang L, Bai X, Zhang X, Wang X, Chen S, Wu S, Lin L. Wang L, et al. Ann Clin Lab Sci. 2023 Nov;53(6):920-930. Ann Clin Lab Sci. 2023. PMID: 38182151

2

hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.

Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ. Osei-Amponsa V, et al. Mol Cell. 2024 Feb 1;84(3):522-537.e8. doi: 10.1016/j.molcel.2023.11.035. Epub 2023 Dec 26. Mol Cell. 2024. PMID: 38151017

3

HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis.

Emmons MF, Bennett RL, Riva A, Gupta K, Carvalho LADC, Zhang C, Macaulay R, Dupéré-Richér D, Fang B, Seto E, Koomen JM, Li J, Chen YA, Forsyth PA, Licht JD, Smalley KSM. Emmons MF, et al. Nat Commun. 2023 Nov 29;14(1):7759. doi: 10.1038/s41467-023-43519-1. Nat Commun. 2023. PMID: 38030596 Free PMC article.

4

HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry.

Rajaraman S, Balakrishnan R, Deshmukh D, Ganorkar A, Biswas S, Pulya S, Ghosh B. Rajaraman S, et al. Future Med Chem. 2023 May;15(10):885-908. doi: 10.4155/fmc-2023-0054. Epub 2023 May 25. Future Med Chem. 2023. PMID: 37227732 Review.

5

Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.

Zhou X, Chen H, Shi Y, Li J, Ma X, Du L, Hu Y, Tao M, Zhong Q, Yan D, Zhuang S, Liu N. Zhou X, et al. Front Immunol. 2023 Feb 23;14:1137332. doi: 10.3389/fimmu.2023.1137332. eCollection 2023. Front Immunol. 2023. PMID: 36911746 Free PMC article.

6

Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages.

Noce B, Di Bello E, Zwergel C, Fioravanti R, Valente S, Rotili D, Masotti A, Salik Zeya Ansari M, Trisciuoglio D, Chakrabarti A, Romier C, Robaa D, Sippl W, Jung M, Häberli C, Keiser J, Mai A. Noce B, et al. ChemMedChem. 2023 Feb 1;18(3):e202200510. doi: 10.1002/cmdc.202200510. Epub 2022 Nov 8. ChemMedChem. 2023. PMID: 36250286

7

PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.

Yang Y, Li M, Zhou X, Wang W, Shao Y, Yao J, Wang X. Yang Y, et al. Ann Clin Lab Sci. 2022 May;52(3):439-451. Ann Clin Lab Sci. 2022. PMID: 35777798

8

NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition.

Tsai CY, Ko HJ, Chiou SJ, Lai YL, Hou CC, Javaria T, Huang ZY, Cheng TS, Hsu TI, Chuang JY, Kwan AL, Chuang TH, Huang CF, Loh JK, Hong YR. Tsai CY, et al. Int J Mol Sci. 2021 May 31;22(11):5907. doi: 10.3390/ijms22115907. Int J Mol Sci. 2021. PMID: 34072831 Free PMC article.

9

HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells.

Ha SD, Lewin N, Li SSC, Kim SO. Ha SD, et al. Cells. 2021 May 4;10(5):1101. doi: 10.3390/cells10051101. Cells. 2021. PMID: 34064422 Free PMC article.

10

Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.

Osko JD, Porter NJ, Decroos C, Lee MS, Watson PR, Raible SE, Krantz ID, Deardorff MA, Christianson DW. Osko JD, et al. J Struct Biol. 2021 Mar;213(1):107681. doi: 10.1016/j.jsb.2020.107681. Epub 2020 Dec 11. J Struct Biol. 2021. PMID: 33316326 Free PMC article.

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