MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice

Eur J Immunol. 2020 Oct;50(10):1602-1605. doi: 10.1002/eji.202048585. Epub 2020 Jul 29.

Abstract

MS4A4A regulates the expression of arginase 1 in macrophages under IL4 stimulation. Also, MS4A4A regulates eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite.

Keywords: IL4; MS4A4A; allergic immunity; arginase 1; macrophage.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Dermatophagoides / immunology
  • Arginase / genetics
  • Arginase / metabolism*
  • Cell Differentiation
  • Eosinophils / immunology*
  • Hypersensitivity / immunology*
  • Lung / immunology*
  • Macrophage Activation
  • Macrophages / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Mice, Knockout
  • Pneumonia / immunology*
  • Pyroglyphidae
  • Up-Regulation

Substances

  • Antigens, Dermatophagoides
  • Membrane Proteins
  • Ms4a4b protein, mouse
  • Arg1 protein, mouse
  • Arginase